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Ontak Drug


Ontak is an anticancer agent called a fusion protein. It is a composion of both interleukin-2 and Diphtheria toxin. It is used to treat certain kinds of lymphoma, leukemia and other conditions as determined by your doctor. It inhibits growth of cancer cells, which results in the death of the cells. Ontak targets cancer cells because they express interleukin-2 receptors.


Ontak can also be necessary for treating malignant melanoma, probably the most widespread explanation for death in skin cancer cases. During the stage IV of the cancer, malignant melanoma tumors were already observed to reduce and some even stabilize when administered this drug. Having extended spirit expectancy from 8 months to one full year in cases - a huge step considering the poor response this cancer has to most treatments.

Ontak is beneficial in treating malignant melanoma. Ontak is frequently prescribed to patients affected by cutaneous T-cell lymphoma, a cancer that affects a provided type of white blood cell and results in lesions to exhibiting one's skin. It has active ingredients of denileukin diftitox.


Ontak is often administered by a doctor of medicine within the hospital. It's endorsed that an enroll in an antihistamine and acetaminophen before collecting the infusion. The dosage varies from patient to patient depending on their age, weight and medical history. Premedicate with an antihistamine and acetaminophen prior to each Ontak infusion is required. The recommended dose is 9 to 18 mcg/kg/day by intravenous infusion over 30 to 60 minutes for 5 consecutive days and every 21days for 8 cycles.

Prepation of Ontak

The vials of Ontak are kept frozen and will be thawed first within the refrigerator at 2 to 8°C (36 to 46°F) although not larger than 24 hours. It may also be thawed at room temperature for 1 to 3 hours before preparing the dose.

- Mix the solution gentle without shaking the vial. Maintain concentration of Ontak at 15 mcg/ml or higher, and don't use glass containers when preparing or holding the solution.

-Use soft plastic IV bags or plastic syringes. When it is ready to be administered, withdraw the correct amount for the dose aloof from vial and inject it into an empty IV bag. And then add sterile saline solution back into the bag, but do not add more than 9 mL of sterile saline for each 1 mL of Ontak.

-It is not recommended to mix ontak with other drugs. Administer prepared solution of within 6 hours using a syringe pump or IV infusion bag and discard unused portions of Ontak immediately.


Patients taking Ontak may have few side effects. Consult your physician promptly if you have any following signs of an allergic reaction of side effect:

  • Difficulty breathing.
  • Swelling of your face, lips, tongue , throat, hands, ankles or feet;
  • Fever, body aches, cough , flu symptoms;
  • Fast heart rate;
  • Back pain, chest pain or tightness,
  • Feeling light-headed, fainting;
  • Warmth or redness in face or neck;
  • Blurred vision, changes in color vision etc.

Some of the less serious side effects are skin itching or rash, weight gain or loss, mild diarrhea or constipation, nausea, vomiting and loss of appetite.


Doctors need to look out for capillary leak syndrome, which can occur anytime during the course of the treatment and can cause death too. Edema, serum albumin, weight and blood pressure need to be checked regularly while the patient is going under treatment to prevent this condition.

Vision loss acuity has been reported at times but not limited to loss of color vision. Though most of the patients recover from this side effect, some of them report persistent damage to vision acuity.

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