Drugs list > Accolate

Accolate is an anti-asthma medication which belongs to a class of drugs known as leukotriene receptor antagonists - also know as LTRAs.

The function of this drug is to block the production of certain substances that incite the symptoms of an asthma attack - which include shortness of breath, coughing, wheezing and tightness in the chest. It is a prophylactic medicine administered for the prevention of asthma attacks, and it is not meant to be used as a treatment for an attack that is already existing.

Accolate is also used to treat allergic rhinitis - which includes runny nose, watery eyes, hay fever and other allergy symptoms. Accolate is taken as a tablet twice a day, but it may take several weeks before the asthma symptoms improve. You must be sure that when you take Accolate, it should be on an empty stomach either one hour before or two hours after a meal as food intake will change how your body reacts to this drug.

Effects Of Accolate

Accolate can cause headaches but it should be mild. If you experience a severe or persistent headache, you should consult your doctor right away.

Other effects of Accolate can include infections; fatigue, back pains; nausea; rashes or itchy skin; difficulty in breathing or swallowing; tingling sensation of the hands or feet; loss of appetite; flu-like symptoms; lethargy; anorexia nervosa and jaundice; brownish or dark urine; sore throat; indigestion; puffy eyes; swelling face, lips, tongue, or throat; or hoarseness of voice. You should always consult or inform your doctor if any one of these symptoms appear while taking Accolate.

One more rare side effect of Accolate is hepatic dysfunction. If you experience pain in the upper right quadrant of the abdomen, along with the feelings of fatigue, lethargy, nausea, itchy skin, anorexia and jaundice - you should immediately consult your doctor.

There are other rare cases where you can experience a condition known as systemic eosinophilia or pneumonia, which is expressed as a worsening of your asthmatic symptoms, heart complications, and nerve disorder. Most of these symptoms, however, can be relieved by reducing the dosage of Accolate.

Contraindications Of Accolate

When administering Accolate, caution should be noted especially when used alongside other drugs. If you are taking Warfarin (a blood thinner), you should closely be monitoring yourself while taking both drugs (like Accolate), and may need to reduce or adjust your Warfarin dosage.

Also, be sure that you inform your doctor if you are taking aspirin, tolbutamide, erythromycin, carbamazepine, theophylline, phenytoin, or corticosteroid therapy. You must also inform the doctor of taking any over-the-counter or herbal medications. These substance can alter the manner by which your body processes the medication.

Accolate In Pregnancy

Accolate falls in the category B - which means that it is safe for pregnant women, and will not affect the developing fetus. However, studies show that it is present in breast milk, which makes it unsuitable for infants. Accolate should not be taken when breastfeeding your baby.

With a change in the dosage, it is safe for children 5 years and above. In the case of the elderly, close monitoring should be observed as they may react differently to the medication.

Structural Components Of Accolate

- Molecular formula: C31H33N3O6S

- Chemical IUPAC name: cyclopentyl [3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]

- 1-methyl-indol-5-yl]aminoformat

- Molecular weight: 575.676 g/mol

- Availability: 200mg tablets

Generic name: Zafirlukast

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